: Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect. Mogroside IV, Mogroside V and combinations thereof act as a Toll -Like Receptor -4 agonist and immune stimulant that can be utilized for both therapeutic vaccine design in cancer and for other pathogenic agents; therapy with Mogroside IV, Mogroside V and combinations thereof are also presented to created immune clearance of a viral infection.