Buffers A to Z
The pKa of a buffer is commonly perceived as the pH of the said buffer when the concentrations of the two buffering species are equal, and where the maximum buffering capacity is achieved. However, it is often forgotten, that when defined as above, pKa depends on buffer concentration and temperature. To avoid this problem the concept of “thermodynamic” pKa0 was introduced. pKa0 is pKa of the buffer at infinite dilution (buffer concentration=0) and 25oC. Thus, pKa0 is a true constant specific for a given buffer.
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