1-Propanephosphonic anhydride, 50 wt.% solution in acetonitrile

Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis.T3P also acts as a promoter and water scavenger in the Friedländer annulation reaction.

P 3035 (OTTO) 1-Propanephosphonic anhydride, 50 wt.% solution in acetonitrile Cas 68957-94 - used as an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2).