3-Hydroxypropionitrile, at low 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) surface excesses, has the phospholipid oriented with the polar headgroups pointing out of the solution.
H 1948 (OTTO) 3-Hydroxypropionitrile, 97% Cas 109-78-4 - used as polar solvent to investigate the orientation of the phospholipid at the surface of the polar solvents by neutral impact collision ion scattering spectroscopy and as a reagent for carboxyl protection in peptide synthesis.