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Synonyms: 4-phenylbutanoic acid, 4-Phenylbutyric acid
4-Phenylbutyric acid is a chemical chaperone, which suppresses oxidative stress by attenuating endoplasmic reticulum stress. 4-Phenylbutyric acid increases the expression of type 2 deiodinase (D2), via the accumulation of Dio2 mRNA. Studies indicate that 4-Phenylbutyric acid affects genes such as Ucp-1, Ucp-3 and Pgc-1α in a D2-dependent manner. The activation of these genes is thought to increase T3 production. Diabetic studies conducted on mice suggest that 4-Phenylbutyric acid normalizes serum glucose levels.
P 1642 (OTTO) 4-Phenylbutyric acid, 98% Cas 1821-12-1 - used as a chemical chaperone involved in protein-folding disorders. It is involved in the synthesis of dyes and an active pharmaceutical ingredient intermediate.
Safety Statements 22-24/25
Certificate Of Analysis
(For eg. B 1615-0108)
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555-16-8
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111-15-9
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99-34-3
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