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Synonyms: Camptothecin
Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumor activity, and reversibly inhibit Mitochondrial Topo I (nuclear Topo I (topoisomerase I)) by binding to and stabilizing the topoisomerase-DNA covalent complex.
C 0778 (OTTO) (S)-(+)-Camptothecin, 90% Cas 7689-03-4 - used this knowledge to unearth new mechanisms of action for inhibiting cancer cell growth
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